Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/952
Title: DESENSITIZATION OF RESPONSES TO NORADRENALINE AND POTASSIUM CHLORIDE IN THE RAT TAIL ARTERY
Authors: UGWU, A. C.
Keywords: Rat tail artery
desensitization
noradrenaline
potassium chloride
calcium sensitivity
Issue Date: 1990
Publisher: Med. Sci. Res.
Series/Report no.: Vol. 18;pp. 659-660.
Abstract: Previous investigators could not account for the factors causing the initial decline between the first and subsequent responses. They rather had neglected the first few responses or the first concentration response curve (CRC) in the name of allowing the tissue to stabilize. The second or even the third CRC is often taken to represent the control curve for the analysis of drugs. For clarity, this study investigated the problem because the basis of this difference is unclear and it is unreasonable to assume thatthe initial state is as likely to reflect the physiological properties of the tissue as does the subsequently desensitized condition. Clearly, both cannot do so. There was a progressive shift which decreased after the first calcium concentration-response curve (CCRC) in the rat tail artery activated with noradrenaline. After sometime, the tissue “acclimatizes” to this new environment and stabilizes its responses. Desensitization or reduction in tissue responses can thus be prevented by avoiding high [Ca 2+ ] or by allowing recovery by leaving longer intervals between CCRCs, thereby allowing reproducibility of high sensitivity to Ca 2+ , which otherwise is lost.
URI: http://hdl.handle.net/123456789/952
Appears in Collections:Abstracts

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