Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/951
Title: DESENSITISATION AND THE VARIATIONS OF OXYGEN TENSION, BAY K 8644 AND NIFEDIPINE IN A LONGITUDINAL STUDY OF A VASCULAR SMOOTH MUSCLE
Authors: UGWU, A. C.
Keywords: Densitisation
Oxygen tensions
Bay K 8644
nifedipine
longitudinal study
vascular smooth muscle
Issue Date: 1992
Publisher: Ugwu, A. C. and McGrath, J. C.
Series/Report no.: Vol. 1;pp. 31 – 37
Abstract: It is possible that high oxygen tension alters the response beyond the receptor and this may provide that high false information on excitation-contraction contraction. The study thus examined desensitization and the variations of oxygen tension, Bay K 8644 and nifedipinein a longitudinal investigation of a vascular muscle activated by noradrenaline (3μM) and/or KCL (100mM). Maximal changes in the peaks of the pulsatile perfusion pressure waves were measures for calculation of vasoconstrictor responses. Results showed that while nifedipine shifted the curve to the right at 95% 02; bay K 8644 had no significant effect on the control curves; although at lower oxygen tensions of 16% 02and 4% 02, bay K 8644 shifted the curve leftwards. It can be induced that the effects of drugs that modify calcium channel function may be affected in magnitude and quality by the application of excess oxygen in vitro.
URI: http://hdl.handle.net/123456789/951
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