Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/937
Title: HAEMATOLOGICAL VALUES IN SICKLE CELL ANAEMIA IN STEADY STATE AND DURING VASO-OCCLUSIVE CRISIS IN BENIN CITY, NIGERIA.
Authors: Omoti, C. E.
Keywords: Haematological
sickle cell anaemia
values
Issue Date: 2005
Publisher: Annals of African Medicine
Series/Report no.: 4;2
Abstract: The aim of this study is to determine the haematological values, haemoglobin A2 and F that can be used in monitoring the status and management of sickle cell anaemia (SCA) patients. Haematological values were determined in SCA with 200 patients (81.3%) in steady state and 46 patients (18.7%) in vaso-occlusive crisis (VOC) in three centers in Benin City, Nigeria as well as 84 control subjects. Automated Coulter Counter was used to determine the complete blood counts while the foetal haemoglobin was estimated by the modified Betke method and haemoglobin A2 by HbS-free microcolumn chromatography. The mean haemoglobin and haematocrit values in the steady state and VOC were 7.54g/dl ± 2.26, 0.23l/l ±0.06; 7.77g/dl ± 2.25 and 0.24l/l ±0.06 respectively. The total white blood cell count (WBCC) for steady state and VOC were 12.72x109/l ± 7.98, 13.67x109/l ±7.57 respectively, while platelet counts were 342.62x109/l ±143.03 and 352.89x109/l ±144.78 respectively. The mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) in steady state were 79.38fl ± 22.41, 28.31pg ± 3.58 and 32.56g/dl ± 2.27 while in VOC they were 85.50fl ± 8.14, 28.79pg ± 2.78 and 33.76g/dl ± 3.44 respectively. The red cell distribution width (RDW), haemoglobin A2 and haemoglobin F in steady state were 23.76%±6.49, 4.52%±1.16 and 2.17%±1.81 while during VOC they were 21.62%±5.11, 3.82%±1.27 and 2.05%±1.19 respectively. The neutrophil count (P<0.01), MCV (P<0.01) and MCHC (P<0.05) were significantly higher in VOC than steady state while the RDW (P<0.05) and haemoglobin A2 (P<0.01) were significantly higher in steady state than during VOC.
URI: http://hdl.handle.net/123456789/937
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