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Title: Seroprevalence of Maternal and neonatal antibodies to nhuman immunodeficiency and hepatitis B viruses in Benin City, Nigeria
Authors: Onakewhor, J.U.E
Offor, E
Okonofua, F.E
Issue Date: Jul-2002
Publisher: JMBR A peer review journal of Biomedical Sciences.
Series/Report no.: vol.1;pp 32-38
Abstract: Seroprevalence of maternal and neonatal antibodies to human immuno-deficiency virus (HIV) and hepatitis B virus (HBV) was determined in 320 Nigerian paturients through unlinked anonymous study. Five mililitres each of 640 blood samples from consecutive mother-neonatal pairs were screened for HIV antibodies using rapid test kit capillus HIV –I and 2 at the time if delivery. Repeatedly repeated samples were were confirmed by the double test algorithm using a second rapid test kit, immunocomb HIV-1 and 2 bispot test and then with immunocomb II HIV-1 and 2 combfirm. Screening for hepatitis B surface antigen (HbsAg) was done using hepatitis B latex test kit, and repeatedly HBsAg reactive samples were confirmed positive using ELISA kits. The maternal seroprevalence for HIV antibodies and HbsAG were 2.5% and 2.2% respectively. The neonatal seroprevalence was 0.9%. The vertical transmission rates were 37.5% for HIV antibodies and 42.9% for HbsAg. None of the neonatal and maternal samples tested positive for both infections. Obstetric co-infection with HIV and HBV is a rare phenomenon in our paturients. However, aseither occurs frequently, we recommend routine universal screening ofpregnant women for both infections in our setting.
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