Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1398
Title: Health Related Quality of Life in Sickle Cell Disease Subjects in Benin City
Authors: Nwogoh, B
Ofovwe, CE
Omoti, CE1
Issue Date: 2016
Publisher: University of Benin
Abstract: Background: Sickle cell disease (SCD) is a chronic disease associated with increased morbidity and mortality. Haemoglobinopathies are the most prevalent genetic disease globally and SCD is estimated to affect 2 – 3% of Nigerians.1 The prevalence of the SCD in Benin City is 2.39%;2 thus it affects a significant proportion of our population. The disease impacts adversely on the quality of life of affected persons. This study aims to evaluate the health related quality of life of sickle cell disease subjects compared to normal controls living in Benin City, Nigeria. Method: The health related quality of life (HRQoL) of SCD subjects was evaluated using the Medical Outcome Study (MOS) 36 item survey tool.3 The outcome was compared with those of a normal non SCD population. Data was analyzed with SPSS version 16. P value was set at 0.05. Result: Sixty one SCD subjects and 46 normal respondent (controls) participated in the study. The mean ages of the SCD group and controls were 26.7 ± 9.0yrs and 24.0 ± 3.4yrs. Fifty nine (96.7%) of the SCD respondents were Hb SS and 2 (3.3%) were Hb SC (table I). The physical function, limitations due to physical health, general health and pain scores were significantly lower in the SCD population compared to the controls (p values < 0.05 each) (table II). The social function and limitation due to emotional problem do not differ significantly between both groups while the vitality (energy/fatigue) score and emotional well being were higher in the SCD group though only the later was statistically significant (p values <0.05 each) (table III). Male gender, employment, clinic attendance and family support impacted positively on the HRQoL of SCD subjects (table IV). 2 Table I: Sociodemographic Parameters of Sickle Cell Disease Respondents Variables SCD Controls Mean ± SD Mean ± SD P value Age (years) 26.7 ± 9.0 24.0 ± 3.4 0.058 Gender Frequency (%) Frequency (%) Males 24 (39.3) 29 (63.0) 0.015 Females 37 (60.7) 17 (37.0) Level of Education Primary 2 (3.3) Secondary 22 (36.1) Tertiary 30 (49.2) 46 (100.0) Postgraduate 6 (9.8) No response 1 (1.6) Marital Status Single 50 (82.0) 43 (93.5) Married 8 (13.1) 3 (6.5) Widow (er) 2 (3.3) No Response 1 (1.6) Job Status Employed 21 (34.4) Unemployed/Students 34 (57.4) 46 (100.0) No response 5 (8.2) Hb Genotype SS 59 (96.7) SC 2 (3.3) AA 19 (41.3) AS 6 (13.0) AC 1 (2.2) No Response 20 (43.5) Clinic Attendance Regular 27 (44.3) Irregular 29 (47.5) NA No Response 5 (8.2) Drug Compliance Yes 48 (78.7) No 10 (16.4) NA No Response 3 (4.9) Sponsorship Self 21 (34.4) NA Non Self (Family/Charity) 39 (63.9) No Response 1 (2.6) Religion Christians 59 (96.7) 46 (100.0) Moslems 1 (1.6) No Response 1 (1.6) 3 Table II: Comparism of MOS subscale scores SCD respondents with those Controls Table III: Comparism of MOS subscale scores between Male and Female SCD respondents MOS Subscales Males Mean ± SD Females Mean ± SD P value Physical Function 12.98 ± 12.99 15.36 ± 12.51 0.481 Role of limitation due to physical health challenge 51.32 ± 43.68 51.00 ± 44.77 0.981 Role of limitation due to emotional problem 47.06 ± 42.59 51.28 ± 45.44 0.762 Energy/Fatigue 71.96 ± 12.77 67.12 ± 15.08 0.206 Emotional wellbeing 80.65 ± 10.85 71.24 ± 14.79 0.011 Social Funtioning 72.28 ± 24.12 66.89 ± 25.21 0.416 Pain 68.15 ± 27.31 54.93 ± 29.15 0.086 General Health 56.77 ± 25.82 58.31± 22.59 0.807 MOS 36 Subscales SCD Mean ± SD Control Mean ± SD P value Physical Function 14.4 ± 12.64 94.78 ± 10.85 <0.001 Role of limitation due to physical health challenge 51.14 ± 43.78 77.72 ± 35.84 0.002 Role of limitation due to emotional problem 49.61 ± 43.87 50.00 ± 44.31 0.967 Energy/Fatigue 68.97 ± 14.32 60.22 ± 21.00 0.012 Emotional wellbeing 74.85 ± 14.09 68.61 ± 20.41 0.066 Social Funtioning 68.96 ± 24.73 71.74 ± 23.63 0.560 Pain 60.00 ± 28.96 73.75 ± 25.25 0.012 General Health 57.70 ± 23.71 71.52 ± 21.70 0.003 4 Table 1V: Linear regression analysis of MOS subscales with Subject Demographic parameters, Clinic attendance and drug compliance PF : Physical function; LPH: limitations due to physical health; LEP: limitations due to emotional health; EF: energy/fatigue; EWB: emotional wellbeing; SF: social funtion; GH: general health Variables PF LPH LEP EF EWB SF PAIN GH Age r -0.137 -0.225 -0.051 -0.151 -0.159 -0.020 0.109 0.023 P value 0.333 0.181 0.769 0.286 0.259 0.887 0.442 0.873 Gender r 0.093 -0.004 0.048 -0.166 -0.327 -0.107 -0.224 0.032 P value 0.481 0.981 0.762 0.206 0.011 0.416 0.086 0.807 LOE r -0.218 0.201 -0.048 0.024 0.156 0.055 0.107 0.275 P value 0.097 0.196 0.762 0.858 0.238 0.677 0.420 0.033 Marital Status r 0.194 0.168 0.179 -0.222 -0.220 0.024 -0.005 -0.011 P value 0.141 0.276 0.251 0.091 0.094 0.859 0.970 0.933 Job Status r 0.132 -0.264 0.173 -0.293 -0.227 -0.231 -0.266 -0.199 P value 0.336 0.100 0.293 0.030 0.096 0.089 0.049 0.141 Clinic Attendance r -0.228 -0.056 -0.382 0.346 0.274 0.088 0.050 0.074 P value 0.093 0.731 0.016 0.010 0.043 0.525 0.716 0.588 Drug Compliance r -0.120 0.183 0.244 0.036 0.215 0.094 -0.160 -0.085 P value 0.374 0.251 0.124 0.791 0.108 0.487 0.236 0.527 Sponsorship r 0.165 -0.134 0.082 -0.257 -0.196 -0.149 -0.173 -0.090 P value 0.208 0.385 0.600 0.049 0.137 0.137 0.189 0.492 Religion r -0.227 -0.259 0.180 0.038 0.091 0.156 -0.210 0.028 P value 0.084 0.094 0.253 0.773 0.492 0.237 0.110 0.830 5
URI: http://hdl.handle.net/123456789/1398
Appears in Collections:Ubard 2016

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