Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1183
Title: BETA THALASSAEMIA TRAITS IN NIGERIAN PATIENTS WITH SICKLE CELL ANAEMIA
Authors: OMOTI, CE
Keywords: co-inheritance
beta thalassaemia
sickle cell anaemia
Issue Date: 2005
Publisher: Journal of Medicine and Biomedical Research
Series/Report no.: 4(1);37-43.
Abstract: Haematological values were determined in two hundred and forty-six sickle cell anaemia (SCA) patients in 3 centers in Benin City, Nigeria as well as eighty-four control subjects with haemoglobin A (HbAA) confirmed byhaemoglobin electrophoresis at pH 8.6. Automated Coulter Counter was used to determine the complete blood counts while the foetal haemoglobin was estimated by the modified Betke method and haemoglobin A2by the HbS-free microcolumn chromatography. Six patients (2.4%) comprising of two males and four females out of the 246 SCA patients were found to have elevated haemoglobin A2(>3.5%). All the six patients also had elevated haemoglobin F (≥1.5%). The family members of three of these six patients weresuccessfully screened. These three patients (1.2%) were found to have a positive co-inheritance of thalassaemia trait and sickle cell anaemia. The erythrocyte indices were all reduced in these selected families except for one family whose mean cell haemoglobin concentration was within normal range. The peripheral blood film revealed the presence of target cellsand occasional microcytes apart from the sickled cells. The possibility ofco-inheritance of the beta thalassaemia gene with the sickle cell gene occurs in about 1.2% of Nigerians with sickle cell anaemia
URI: http://hdl.handle.net/123456789/1183
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