Please use this identifier to cite or link to this item:
Issue Date: 19-Jun-2014
Publisher: University of Benin Press
Series/Report no.: Inaugural Lecture Series;141
Abstract: This lecture discusses the interwoven nature of the component parts of the cardiovascular system (CVS) the heart (pump) , the blood vessels ( conduits) and the blood (transport medium) looking specifically at how vascular reactivity in response to its chemical environment can actually influence the heart’s p umping ability and consequen tly effectiveness of the blood in all its roles as a transporter, distributor, regulator, protector controller and provider. Several interventions to modify the bio chemical environment of the blood vessels have been used to study their reactivity and bein g so interwoven with the heart and the blood any changes in them would consequently affect the functi ons of both the heart and the b lood. The major part this lecture will be addressing is how pH which is a measure of acidity and alkalinity of a solution ca n affect the smooth muscle cells found in the walls of the blood vessels. In response to their chemical and biological environment these vascular smooth muscles (VSM) will either contract or dilate to subsequently influence the pumping ability of the heart which in turn will affect the effective functions of the blood which we all know is very vital to life. pH was modified severally and t he mechanisms by which both extracellular (pH 0 ) and intracellular pH (pH i) affect vascular tone, and by which pH i itself is regulated in the vascular smooth muscle cells, were investigated. pHi was modified at constant pHo using two different procedures, one was the application and withdrawal of CO 2 and the other was the "NH 4 + pulse" technique, which involved the application and washout of NH4 + . One significant thing about this work is that it pioneered the use of the "NH4 + pulse" technique in the vascular smooth muscle. The majority of experiments were carried out with isolated rabbit ears activated with 10 -6 M noradrenaline and perfused at constant flow. Other preparations studied were perfused whole femor al be ds of r abbit s , f ro g wh o le b od y a nd r at tail ar te r y . Th e p e r fusi n g solutions were phosphate, Hepes or CO 2 / HCO3 --buffered Ringer's having Cl -as the bulk anion, and appropriately oxygenated.
Appears in Collections:University of Benin Inaugural lectures

Files in This Item:
File Description SizeFormat 
141st inaugural_lecture_ighoroje_2.pdf743.38 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.